Specialization of B-type cyclins for mitosis or meiosis in S. cerevisiae

Dahmann, C., Futcher, B. (1995) Specialization of B-type cyclins for mitosis or meiosis in S. cerevisiae. Genetics, 140 (3). pp. 957-63. ISSN 0016-6731 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7672594

Abstract

The CLB1, CLB2, and CLB3 genes encode B-type cyclins important for mitosis in Saccharomyces cerevisiae, while a fourth B-type cyclin gene, CLB4, has no clear role. The effects of homozygous clb mutations on meiosis were examined. Mutants homozygous for clb1 clb3, or for clb1 clb4, gave high levels of sporulation, but produced mainly two-spored asci instead of four-spored asci. The cells had completed meiosis I but not meiosis II, producing viable diploid ascospores. CLB1 and CLB4 seem to be much more important for meiosis than for mitosis and may play some special role in meiosis II. In contrast, CLB2 is important for mitosis but not meiosis. The level of Cdc28-Clb activity may be important in determining whether meiosis II will occur.

Item Type: Paper
Uncontrolled Keywords: Centromere Comparative Study Cyclins/genetics/ physiology Diploidy Genetic Markers Genotype Meiosis Mitosis Mutagenesis Research Support, U.S. Gov't, P.H.S. Saccharomyces cerevisiae/cytology/genetics/ growth & development
Subjects: organism description > yeast > Saccharomyces
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome > centromere
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome > centromere

organs, tissues, organelles, cell types and functions > organelles, types and functions > meiosis
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations > mutagenesis
CSHL Authors:
Communities: CSHL labs > Futcher lab
Depositing User: Jessica Koos
Date: July 1995
Date Deposited: 12 Aug 2014 14:26
Last Modified: 12 Aug 2014 14:26
PMCID: PMC1206679
URI: http://repository.cshl.edu/id/eprint/30585

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