The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity

Chapman, P. F., Frenguelli, B. G., Smith, A., Chen, C. M., Silva, A. J. (March 1995) The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity. Neuron, 14 (3). pp. 591-7. ISSN 0896-6273 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7695905
DOI: 10.1016/0896-6273(95)90315-1

Abstract

The alpha-Ca2+/calmodulin kinase II (alpha CaMKII) is required for long-term potentiation in the CA1 region of the hippocampus. Here, we report that this kinase also has a crucial role in presynaptic plasticity. Paired-pulse facilitation is blunted in the CA1 region of mice heterozygous for a targeted mutation of alpha CaMKII, confirming that this kinase can promote neurotransmitter release. Unexpectedly, field and whole-cell recordings of posttetanic potentiation show that the synaptic responses of mutants are larger than those of controls, indicating that alpha CaMKII can also inhibit transmitter release immediately after tetanic stimulation. Thus, alpha CaMKII has the capacity either to potentiate or to depress excitatory synaptic transmission depending on the pattern of presynaptic activation.

Item Type: Paper
Uncontrolled Keywords: Animals Ca(2+)-Calmodulin Dependent Protein Kinase/genetics/ metabolism Crosses, Genetic Electric Stimulation Evoked Potentials Heterozygote Hippocampus/ physiology In Vitro Long-Term Potentiation Mice Mice, Inbred C57BL Mice, Neurologic Mutants Mutation Neuronal Plasticity Patch-Clamp Techniques Pyramidal Cells/ physiology Research Support, Non-U.S. Gov't Synapses/ physiology Time Factors
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
organism description > animal
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs
Depositing User: Jessica Koos
Date: March 1995
Date Deposited: 15 Aug 2014 19:18
Last Modified: 15 Aug 2014 19:18
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30572

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