A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Pulido, R., Baker, S. J., Barata, J. T., Carracedo, A., Cid, V. J., Chin-Sang, I. D., Dave, V., den Hertog, J., Devreotes, P., Eickholt, B. J., Eng, C., Furnari, F. B., Georgescu, M. M., Gericke, A., Hopkins, B., Jiang, X., Lee, S. R., Losche, M., Malaney, P., Matias-Guiu, X., Molina, M., Pandolfi, P. P., Parsons, R., Pinton, P., Rivas, C., Rocha, R. M., Rodriguez, M. S., Ross, A. H., Serrano, M., Stambolic, V., Stiles, B., Suzuki, A., Tan, S. S., Tonks, N. K., Trotman, L. C., Wolff, N., Woscholski, R., Wu, H., Leslie, N. R. (July 2014) A Unified Nomenclature and Amino Acid Numbering for Human PTEN. Science signaling, 7 (332). pe15. ISSN 1937-9145

URL: http://www.ncbi.nlm.nih.gov/pubmed/24985344
DOI: 10.1126/scisignal.2005560

Abstract

The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > PTEN
CSHL Authors:
Communities: CSHL labs > Tonks lab
CSHL labs > Trotman lab
CSHL Cancer Center Program > Signal Transduction
Depositing User: Matt Covey
Date: 1 July 2014
Date Deposited: 11 Jul 2014 16:38
Last Modified: 16 Oct 2015 14:50
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30505

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