Activity of creatine kinase in sera from healthy women, carriers of Duchenne muscular dystrophy and cord blood, determined by the "European" recommended method with NAC-EDTA activation

Moss, D. W., Whitaker, K. B., Parmar, C., Heckmatt, J., Wikowski, J., Sewry, C., Dubowitz, V. (October 1981) Activity of creatine kinase in sera from healthy women, carriers of Duchenne muscular dystrophy and cord blood, determined by the "European" recommended method with NAC-EDTA activation. Clinica chimica acta; international journal of clinical chemistry, 116 (2). pp. 209-16. ISSN 0009-8981 (Print)0009-8981

URL: http://www.ncbi.nlm.nih.gov/pubmed/6794955

Abstract

Creatine kinase activity has been measured at 37 degrees C in sera from healthy women, carriers of Duchenne muscular dystrophy and cord blood, with activation by N-acetyl cysteine (NAC) and EDTA as recommended by several European committees on standardisation. The upper limit of the reference range for healty women was found to be 170 U/l. The distributions of creatine kinase activities in healthy and carrier women have been used to calculate probability of carrier status as a function of creatine kinase activity. Although the range of creatine kinase activities in normal cord blood is wide, the data provide a basis for interpretation when Duchenne muscular dystrophy is suspected.

Item Type: Paper
Uncontrolled Keywords: Acetylcysteine/*pharmacology Adolescent Adult Creatine Kinase/*blood/genetics Edetic Acid/*pharmacology Female Fetal Blood/*enzymology Heterozygote Detection Humans Kinetics Middle Aged Muscular Dystrophies/*enzymology/genetics Pregnancy Reference Values
Subjects: diseases & disorders > congenital hereditary genetic diseases > muscular dystrophy
CSHL Authors:
Communities: Banbury Center
Depositing User: Matt Covey
Date: 26 October 1981
Date Deposited: 26 Nov 2014 19:24
Last Modified: 26 Nov 2014 19:24
URI: http://repository.cshl.edu/id/eprint/30422

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