Freeze-fracture analysis of plasma membranes in Duchenne muscular dystrophy. A study using cultured skin fibroblasts

Jones, G. E., Severs, N. J., Witkowski, J. A. (February 1983) Freeze-fracture analysis of plasma membranes in Duchenne muscular dystrophy. A study using cultured skin fibroblasts. Journal of the Neurological Sciences, 58 (2). pp. 185-93. ISSN 0022510X (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/6300339

Abstract

Quantitative freeze-fracture studies of the numercial density and distribution of intramembrane particles (IMP) were carried out on the plasma membrane of cultured skin fibroblasts from 4 patients with Duchenne muscular dystrophy and 3 normal controls. Analysis of P and E fracture faces of the fibroblast plasma membrane failed to show any significant differences in either IMP density or distribution between normal and dystrophic specimens. In contrast to previous reports, our results indicate that an altered IMP density is not a characteristic feature of the dystrophic cell membrane.

Item Type: Paper
Uncontrolled Keywords: Cell Adhesion Cell Aggregation Cell Membrane/*ultrastructure Cells, Cultured Fibroblasts/ultrastructure Freeze Fracturing Humans Inclusion Bodies/ultrastructure Muscular Dystrophies/*pathology
Subjects: Investigative techniques and equipment > cell culture
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts

diseases & disorders > congenital hereditary genetic diseases > muscular dystrophy
CSHL Authors:
Communities: Banbury Center
Depositing User: Matt Covey
Date: February 1983
Date Deposited: 21 Nov 2014 22:21
Last Modified: 21 Nov 2014 22:21
URI: http://repository.cshl.edu/id/eprint/30416

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