Imposing specificity by localization: mechanism and evolvability

Ptashne, M., Gann, A. (1999) Imposing specificity by localization: mechanism and evolvability. Evolution as Computation: Dimacs Workshop, Princeton, January 1999 . Springer Berlin Heidelberg. ISBN 9783540667094

URL: http://books.google.com/books?id=XBwv3BlGVK0C

Abstract

Cells detect extracellular signals by allostery and then give those signals meaning by "regulated localization". We suggest that this formulation applies to many biological processes and is particularly well illustrated by the mechanisms of gene regulation. Analysis of these mechanisms reveals that regulated localization requires simple molecular interactions that are readily used combinatorially. This system of regulation is highly "evolvable", and its use accounts, at least in part, for the nature of the complexities observed in biological systems

Item Type: Book
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation
CSHL Authors:
Communities: Watson School
Depositing User: Matt Covey
Date: 1999
Date Deposited: 23 Jun 2014 19:35
Last Modified: 23 Jun 2014 19:35
URI: http://repository.cshl.edu/id/eprint/30327

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving