Random monoallelic expression: Regulating gene expression one allele at a time

Eckersley-Maslin, M. A., Spector, D. L. (2014) Random monoallelic expression: Regulating gene expression one allele at a time. Trends in Genetics, 30 (6). pp. 237-244. ISSN 13624555

URL: http://www.ncbi.nlm.nih.gov/pubmed/24780084
DOI: 10.1016/j.tig.2014.03.003

Abstract

Monoallelic gene expression is a remarkable process in which transcription occurs from only one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of autosomal genes exhibit random monoallelic gene expression, in which different cells express only one allele independently of the underlying genomic sequence, in a cell type-specific manner. Recently, genome-wide studies have increased our understanding of the cell type-specific incidence of random monoallelic gene expression, and how the imbalance in allelic expression is distinguished within the cell and potentially maintained across cell generations. Monoallelic gene expression is likely generated through stochastic independent regulation of the two alleles upon differentiation, and has varied implications for the cell and organism, in particular with respect to disease. © 2014 Elsevier Ltd.

Item Type: Paper
Uncontrolled Keywords: Monoallelic expression Stochastic gene regulation
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation
CSHL Authors:
Communities: CSHL labs > Spector lab
CSHL Cancer Center Shared Resources > Genetic Screening Service
CSHL Cancer Center Shared Resources > Microscopy Service
Watson School > Publications
Depositing User: Matt Covey
Date Deposited: 13 Jun 2014 14:16
Last Modified: 23 Jan 2015 20:50
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30301

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