Is 1 Hz rTMS Always Inhibitory in Healthy Individuals?

Caparelli, E., Backus, W., Telang, F., Wang, G., Maloney, T., Goldstein, R., Henn, F. (2012) Is 1 Hz rTMS Always Inhibitory in Healthy Individuals? Open Neuroimaging Journal, 6. pp. 69-74.

URL: http://www.ncbi.nlm.nih.gov/pubmed/22930669
DOI: 10.2174/1874440001206010069

Abstract

1 Hz repetitive Transcranial Magnetic Stimulation (rTMS) is considered to have an inhibitory effect in healthy people because it suppresses the excitability of the motor or visual cortex that is expressed as an increase in the motor or the phosphene threshold (PT), respectively. However, the underlying mechanisms and the brain structures involved in the action of rTMS are still unknown. In this study we used two sessions of simultaneous TMS-functional magnetic resonance imaging (fMRI), one before and one after, 15 minutes of 1Hz rTMS to map changes in brain function associated with the reduction in cortical excitability of the primary visual cortex induced by 1 Hz rTMS, when TMS was applied on the occipital area of healthy volunteers. Two groups were evaluated, one group composed of people that can see phosphenes, and another of those lacking this perception. The inhibitory effect, induced by the 1 Hz rTMS, was observed through the increase of the PT, in the first group, but did not lead to a global reduction in brain activation, instead, showed change in the activation pattern before and after rTMS. Conversely, for the second group, changes in brain activation were observed just in few brain areas, suggesting that the effect of 1 Hz rTMS might not be inhibitory for everyone and that the concept of inhibitory/excitatory effect of rTMS may need to be revised.

Item Type: Paper
Uncontrolled Keywords: TMS-functional magnetic resonance imaging phosphene threshold.
Subjects: Investigative techniques and equipment > magnetic resonance imaging
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 2012
Date Deposited: 06 Jun 2014 16:39
Last Modified: 06 Jun 2014 16:39
PMCID: PMC3428632
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30277

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