Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas

Kircher, T., Thienel, R., Wagner, M., Reske, M., Habel, U., Kellermann, T., Frommann, I., Schwab, S., Wolwer, W., von Wilmsdorf, M., Braus, D. F., Schmitt, A., Rapp, A., Stocker, T., Shah, N. J., Henn, F. A., Sauer, H., Gaebel, W., Maier, W., Schneider, F. (March 2009) Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas. European Archives of Psychiatry and Clinical Neuroscience, 259 (2). pp. 72-9. ISSN 0940-1334 (Print)0940-1334 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/18806920
DOI: 10.1007/s00406-008-0837-4

Abstract

The Neuregulin (NRG1) gene has been associated with schizophrenia, but its functional implications are largely unknown. Our aim was to assess differential brain activation between patients carrying an at-risk allele on the Neuregulin 1 gene and patients without this genetic risk. Neural signal changes between 14 first episode schizophrenia patients with the at risk allele (SNP8NRG221533) from the Icelandic core haplotype and 14 without were measured with fMRI during a working memory task. Patients without the at risk allele showed greater activations (P < 0.05; corrected) in the left hippocampus, precuneus and cerebellum, as well as the right anterior cingulate. Brain regions previously associated with the pathology of Schizophrenia are differentially affected in those with a genetic at risk status in the NRG1 gene. Heterogeneity of structural and functional measures within patients characterized by clinical phenotypes may be in part due to this genetic variation.

Item Type: Paper
Uncontrolled Keywords: Adult Cerebellum/physiopathology Cerebral Cortex/pathology/*physiopathology Female Frontal Lobe/physiopathology Functional Laterality/genetics Genetic Predisposition to Disease/genetics Gyrus Cinguli/physiopathology Haplotypes/*genetics Hippocampus/physiopathology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Neuregulin-1/*genetics Polymorphism, Single Nucleotide/*genetics Schizophrenia/diagnosis/*genetics/*physiopathology Temporal Lobe/physiopathology Young Adult
Subjects: diseases & disorders > mental disorders > schizophrenia
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > single nucleotide polymorphism
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: March 2009
Date Deposited: 06 Jun 2014 18:27
Last Modified: 06 Jun 2014 18:27
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30261

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