In vitro neurotransmitter release in an animal model of depression

Edwards, E., Kornrich, W., van Houtten, P., Henn, F. A. (July 1992) In vitro neurotransmitter release in an animal model of depression. Neurochem Int, 21 (1). pp. 29-35. ISSN 0197-0186 (Print)0197-0186

URL: http://www.ncbi.nlm.nih.gov/pubmed/1303140
DOI: 10.1016/0197-0186(92)90065-Y

Abstract

Sprague-Dawley rats exposed to uncontrollable shock can be separated by a subsequent shock escape test into two groups: a "helpless" (LH) group which demonstrates a deficit in escape behavior, and a "nonlearned helpless" (NLH) group which shows no escape deficit and acquires the escape response as readily as naive control rats (NC) do. The present studies were designed to examine the correlations between the behavioral differences and the changes of in vitro neurotransmitter release seen in these three groups of rats. The major finding concerned a significant increase in endogenous and K(+)-stimulated serotonin (5-HT) release in the hippocampal slices of LH rats. There were no apparent differences in acetylcholine, dopamine and noradrenaline release in the hippocampus of LH rats as compared to NLH and NC rats. These results add further support to previous studies in our laboratory which implicate presynaptic 5-HT mechanisms in the behavioral deficit caused by uncontrollable shock.

Item Type: Paper
Uncontrolled Keywords: Acetylcholine/metabolism Animals Depression/metabolism/*physiopathology Disease Models, Animal Dopamine/metabolism Electroshock Escape Reaction *Helplessness, Learned Hippocampus/drug effects/*metabolism Male Norepinephrine/metabolism Potassium/pharmacology Rats Rats, Sprague-Dawley Serotonin/*metabolism
Subjects: diseases & disorders > mental disorders > mood disorders > depression
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neurotransmitter
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > synaptic transmission
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: July 1992
Date Deposited: 09 Jul 2014 14:54
Last Modified: 09 Jul 2014 14:54
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30241

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving