Uptake of adenosine into cultured cerebral endothelium

Beck, D. W., Vinters, H. V., Hart, M. N., Henn, F. A., Cancilla, P. A. (July 1983) Uptake of adenosine into cultured cerebral endothelium. Brain Research, 271 (1). pp. 180-3. ISSN 0006-8993 (Print)0006-8993 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/6883117
DOI: 10.1016/0006-8993(83)91382-3

Abstract

Adenosine uptake by cultured cerebral endothelium is a carrier-mediated process. The Km value for adenosine uptake is 5.0 microM and the vmax is 1.15 nmol/min/mg cell protein. The uptake system is inhibited by the adenosine analog 2-chloroadenosine at low adenosine concentrations. The results prove the existence of a nucleoside transport system associated with cerebral capillary endothelium.

Item Type: Paper
Uncontrolled Keywords: 2-Chloroadenosine Adenosine/analogs & derivatives/*metabolism/pharmacology Animals Biological Transport/drug effects Carbon Radioisotopes/diagnostic use Cell Line Cells, Cultured *Cerebrovascular Circulation/drug effects Dipyridamole/pharmacology Endothelium/drug effects/metabolism Kinetics Mice Papaverine/pharmacology Sucrose/metabolism Tritium/diagnostic use
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > endothelium
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > endothelium
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > endothelium
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 18 July 1983
Date Deposited: 19 Jun 2014 20:44
Last Modified: 19 Jun 2014 20:44
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30228

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