Neurotransmitters and astroglia lead to neuromodulation

Henn, F. (1982) Neurotransmitters and astroglia lead to neuromodulation. Progress in Brain Research, 55. pp. 241-52. ISSN 0079-6123 (Print)0079-6123

URL: http://www.ncbi.nlm.nih.gov/pubmed/6131476
DOI: 10.1016/s0079-6123(08)64201-6

Abstract

The mechanisms which modulate impulse transmission in the CNS are of obvious importance. For stable infomiation processing, it is important that the extracellular environment of neurons be closely regulated. The processing of information appears to be dependent on such diverse mechanisms as presynaptic regulation of transmitter release and electrotonic current spread in dendritic networks. All of these mechanisms depend in part on the extracellular concentration of ions and neuromodulators. Thus, the cellular matrix in which synaptic transmission takes place may also have a functional role to play through controlling the composition of the neuronal environment. Astroglia, which provide the matrix in which unmyelinated axons and synaptic contacts lie, have been implicated in several aspects of regulation of the neuronal environment. They were found initially to act as spatial buffers for K+ ions. This prevents an extracellular buildup of K + during the passage of nerve impulses. Subsequently, astrocytes were shown to contain transport systems capable of removing a variety of neurotransmitters from the extracellular media. Finally, there have been recent suggestions that astroglia contain receptors for putative neurotransmitters or neuroinodulators. A summary of the capacity of astrocytic responses to transmitters or modulators reveals the potential for intercellular regulation of transmission in the CNS.

Item Type: Paper
Uncontrolled Keywords: Amino Acids/physiology Animals Astrocytes/*physiology Biogenic Amines/physiology Biological Transport Brain/*physiology Neurotransmitter Agents/*physiology Spinal Cord/*physiology
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > astrocytes
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > astrocytes
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > astrocytes

neurobiology
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > neurotransmitter
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 1982
Date Deposited: 19 Jun 2014 20:30
Last Modified: 19 Jun 2014 20:30
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30226

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