Investigations concerning the cellular origin of dopamine receptors

Henn, F. A., Titeler, M., Anderson, D. J., May, K. (1978) Investigations concerning the cellular origin of dopamine receptors. Life Sciences, 23 (6). pp. 617-21. ISSN 0024-3205 (Print)0024-3205

URL: http://www.ncbi.nlm.nih.gov/pubmed/692285
DOI: 10.1016/0024-3205(78)90042-5

Abstract

The cellular investigation of dopamine receptors was examined using glial cell fractions and synaptic fractions prepared from bovine caudate. Binding of the dopamine agonist apomorphine and antagonist spiroperidol was examined. A fractionation of bovine substantia nigra was developed. No evidence of haloperidol binding was found in neuronal, glial or synaptosomal fractions from this tissue. Finally, an autoradiographic localication of [3H]-haloperidol was undertaken. The results support the astroglial localization of a significant portion of the dopamine receptors.

Item Type: Paper
Uncontrolled Keywords: Animals Apomorphine/metabolism Astrocytes/metabolism Autoradiography Brain/cytology/*metabolism/ultrastructure Cattle Caudate Nucleus/metabolism Rats Receptors, Dopamine/*metabolism Spiperone/metabolism Substantia Nigra/metabolism Synaptosomes/metabolism
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dopamine
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dopamine receptor
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date Deposited: 09 Jul 2014 15:29
Last Modified: 09 Jul 2014 15:29
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30216

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