Henn, F. A., Titeler, M., Anderson, D. J., May, K. (August 1978) Investigations concerning the cellular origin of dopamine receptors. Life Sciences, 23 (6). pp. 617-21. ISSN 0024-3205 (Print)0024-3205
Abstract
The cellular investigation of dopamine receptors was examined using glial cell fractions and synaptic fractions prepared from bovine caudate. Binding of the dopamine agonist apomorphine and antagonist spiroperidol was examined. A fractionation of bovine substantia nigra was developed. No evidence of haloperidol binding was found in neuronal, glial or synaptosomal fractions from this tissue. Finally, an autoradiographic localication of [3H]-haloperidol was undertaken. The results support the astroglial localization of a significant portion of the dopamine receptors.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Apomorphine/metabolism Astrocytes/metabolism Autoradiography Brain/cytology/*metabolism/ultrastructure Cattle Caudate Nucleus/metabolism Rats Receptors, Dopamine/*metabolism Spiperone/metabolism Substantia Nigra/metabolism Synaptosomes/metabolism |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dopamine bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dopamine receptor |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | 14 August 1978 |
| Date Deposited: | 09 Jul 2014 15:29 |
| Last Modified: | 09 Jul 2014 15:29 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30216 |
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