Dopamine and schizophrenia. A therapy revisited and revised

Henn, F. A. (August 1978) Dopamine and schizophrenia. A therapy revisited and revised. Lancet, 2 (8084). pp. 293-5. ISSN 0140-6736 (Print)0140-6736

URL: http://www.ncbi.nlm.nih.gov/pubmed/79086
DOI: 10.1016/S0140-6736(78)91693-8

Abstract

Evidence is presented for a modulatory role for dopamine in the C.N.S. and for an indirect rather than a direct involvement of dopaminergic systems in the production of schizophrenic symptoms. The fine structure of dopaminergic fibres indicates that a majority of presynaptic boutons are not in close juxtaposition with postsynaptic neuronal membranes. This points to a wider distribution of receptors than localisation to dense postsynaptic membrane. Preliminary studies of receptor localisation support this conclusion, providing indirect evidence for autoreceptors and evidence for localisation, in the glia, of a substantial number of receptors.

Item Type: Paper
Uncontrolled Keywords: Adenylate Cyclase/antagonists & inhibitors/metabolism Animals Astrocytes/analysis/enzymology Cattle Caudate Nucleus/cytology Cyclic AMP/biosynthesis Dopamine/*physiology Haloperidol/pharmacology Humans Phenothiazines/pharmacology Rabbits Rats Receptors, Dopamine/drug effects/isolation & purification/*physiology Schizophrenia/*etiology
Subjects: diseases & disorders > mental disorders > schizophrenia
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 5 August 1978
Date Deposited: 09 Jul 2014 15:24
Last Modified: 09 Jul 2014 15:24
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30214

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