Glial cell function: active control of extracellular K + concentration

Henn, F. A., Haljamae, H., Hamberger, A. (August 1972) Glial cell function: active control of extracellular K + concentration. Brain Research, 43 (2). pp. 437-43. ISSN 0006-8993 (Print)0006-8993 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/4262289
DOI: 10.1016/0006-8993(72)90399-X

Abstract

To investigate the ability of the glial cell to control the extracellular K+ ion concentration in the CNS 3 kinds of experiment were carried out. (1) The ability of isolated cell fractions enriched in glia or neurons to reaccumulate K+ was measured. (2) The activation of the Na+single bondK+-ATPase by K+ was measured on these isolated cell suspensions. (3) Plasma membrane fractions were prepared from neurons and glia and the Na+single bondK+-ATPase activity was studied as a function of K+ ion concentration. The glial cell Na+single bondK+-ATPase was always more active, approximately 2.5- to 4-fold, and markedly more sensitive to variations in the K+ ion concentration than the neuronal ATPase. These results support the idea that control of the extracellular K+ ion concentration in the CNS is at least in part dependent on the metabolically coupled sodium-potassium pump of the glial cell.

Item Type: Paper
Uncontrolled Keywords: Adenosine Triphosphatases/physiology Animals Biological Transport, Active Brain/*metabolism Buffers Cell Membrane/enzymology Cerebral Cortex/metabolism *Extracellular Space Inulin/metabolism Neuroglia/enzymology/*physiology Neurons/*metabolism Potassium/*metabolism Rabbits Sodium/metabolism Tritium
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > glia cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > glia cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > glia cells
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: 25 August 1972
Date Deposited: 09 Jul 2014 18:41
Last Modified: 09 Jul 2014 18:41
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30200

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving