In vivo development of neuronal structure and function

Cline, H. T., Wu, G.-Y., Malinow, R. (1996) In vivo development of neuronal structure and function. Cold Spring Harbor Symposia on Quantitative Biology, 61. pp. 95-104. ISSN 00917451 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/9246439
DOI: 10.1101/SQB.1996.061.01.013

Abstract

The formation of the nervous system requires a coordinated development of neuronal morphology and synaptic physiology. We have used the frog retinotectal system to examine the development of brain structure and function. The retinotectal system of frogs is well known for its developmental and experience-dependent synaptic plasticity. As the animal grows, retinotectal axon arbors migrate considerable distances within the contralateral optic tectum in order to maintain a high degree of refinement in the retinotopic map. The capacity of the arbors to move within the tectal neuropil indicates that the retinotectal synapses and axon arbor branches are dynamic. The maintenance of retinotopy despite the axonal mobility indicates that there must be a mechanism which controls sites of synapse formation and stabilization. Considerable evidence supports the hypothesis that N-methyl-d-aspartate (NMDA) receptor activity is required to maintain the retinotopic map (Cline 1991), but it is still not clear how activity influences the neuronal

Item Type: Paper
Uncontrolled Keywords: Animals Axons/physiology/ultrastructure Glutamic Acid/physiology Humans Nervous System/cytology/ growth & development/ultrastructure Neurons/ physiology/ultrastructure Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Synapses/physiology
Subjects: organism description > animal > developmental stage
neurobiology
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Cline lab
CSHL labs > Malinow lab
Depositing User: Matt Covey
Date Deposited: 22 May 2014 14:22
Last Modified: 22 May 2014 14:22
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30178

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