Telomerase and cancer: revisiting the telomere hypothesis

Autexier, C., Greider, C. W. (October 1996) Telomerase and cancer: revisiting the telomere hypothesis. Trends Biochem Sci, 21 (10). pp. 387-91. ISSN 0968-0004 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/8918193
DOI: 10.1016/S0968-0004(96)10042-6

Abstract

Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Division/genetics Cells, Cultured Eukaryotic Cells/enzymology/metabolism Humans Mice Neoplasms/ physiopathology/therapy Research Support, Non-U.S. Gov't Telomerase/antagonists & inhibitors/ metabolism Telomere/ chemistry/genetics/metabolism
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > telomeres
CSHL Authors:
Communities: CSHL labs > Greider lab
Depositing User: Matt Covey
Date: October 1996
Date Deposited: 22 May 2014 15:44
Last Modified: 22 May 2014 15:44
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30169

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving