Potential roles for interactions between the mitochondrial and nuclear DNA throughout the cell cycle of Schizosaccharomyces pombe

Grand, R. S., Martienssen, R., O'Sullivan, J. M. (May 2014) Potential roles for interactions between the mitochondrial and nuclear DNA throughout the cell cycle of Schizosaccharomyces pombe. Mitochondrion, 17. pp. 141-9. ISSN 1567-7249

URL: http://www.ncbi.nlm.nih.gov/pubmed/24815909
DOI: 10.1016/j.mito.2014.04.014

Abstract

Over the course of mitochondrial evolution, the majority of genes required for its function have been transferred and integrated into nuclear chromosomes. Ongoing transfer of mitochondrial DNA to the nucleus has been detected, but its functional significance has not been fully elucidated. Here by Genome Conformation Capture, we identify DNA-DNA interactions between the mitochondrial and nuclear chromosomes (mt-nDNA interactions) that vary in strength and number between the G1, G2 and M phases of the fission yeast cell cycle. Mt-nDNA interactions captured in mitotic anaphase were associated with nuclear genes required for the regulation of cell growth and energy availability. Furthermore, mt-nDNA interactions captured in the G1 phase involved high efficiency, early firing origins of DNA replication. Collectively, these results suggest functional roles for the ongoing transfer of regions of the mitochondrial genome to the nucleus.

Item Type: Paper
Uncontrolled Keywords: Cell cycle Communication DNA replication Genome Conformation Capture (GCC) Mitochondria Regulation
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitochondria
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Martienssen lab
CSHL Cancer Center Program > Gene Regulation and Cell Proliferation
Depositing User: Matt Covey
Date: 7 May 2014
Date Deposited: 15 May 2014 19:16
Last Modified: 06 Oct 2015 21:14
PMCID: PMC4209164
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30140

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