Control of retinotectal axon arbor growth by postsynaptic CaMKII

Zou, D. J., Cline, H. T. (1996) Control of retinotectal axon arbor growth by postsynaptic CaMKII. In: Neural Development and Plasticity. Progress in Brain Research, 108 . Elsevier, Amsterdam, pp. 303-12. ISBN 0079-6123 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/8979810

Abstract

The chapter focuses on the control of retinotectal axon arbor growth by postsynaptic of CaMKII. The in vivo imaging of individual axons in the intact animal permits the observation of growing axons in their normal complex environment These observations have shown that retinal axons gradually elaborate the complex arbor by the profuse addition of excess branches and the stabilization of only a small fraction of the new branches. The elaboration of the axon arbor may be influenced by a variety of factors in the tectal environment including cell surface molecules, the extracellular matrix, growth factors and neuronal activity. It is tested whether the dynamic rearrangements seen in normal axons might reflect the outcome of activity-dependent mechanisms including postsynaptic Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) activity. A selective increase in CaMKII activity in postsynaptic tectal neurons results in the loss of shorter branch tips in the presynaptic retinal axons.

Item Type: Book Section
Uncontrolled Keywords: Animals Axons/ physiology Ca(2+)-Calmodulin Dependent Protein Kinase/ physiology Retina/ ultrastructure Superior Colliculus/ ultrastructure Synapses/ physiology
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > axon > axon arbors
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > CaMKII
organs, tissues, organelles, cell types and functions > tissues types and functions > retina
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: Kathleen Darby
Date: 1996
Date Deposited: 12 May 2014 17:33
Last Modified: 12 May 2014 17:33
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30130

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