CREB and the formation of long-term memory

Yin, J. C., Tully, T. (April 1996) CREB and the formation of long-term memory. Current Opinion in Neurobiology, 6 (2). pp. 264-8. ISSN 0959-4388

URL: http://www.ncbi.nlm.nih.gov/pubmed/8725970
DOI: 10.1016/S0959-4388(96)80082-1

Abstract

Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of the transcription factor accelerate the process. These results have led to the recent hypothesis that CREB is pivotal in the switch from short-term (protein synthesis independent) to long-term (protein synthesis dependent) memory.

Item Type: Paper
Uncontrolled Keywords: Animals Aplysia/physiology Cyclic AMP/physiology Cyclic AMP Response Element-Binding Protein/genetics/ physiology Drosophila/physiology Genes, Switch Memory/ physiology Mice Mice, Knockout/genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > CREB
organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > Cyclic AMP
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Tully lab
CSHL labs > Yin lab
Depositing User: Kathleen Darby
Date: April 1996
Date Deposited: 12 May 2014 17:14
Last Modified: 12 May 2014 17:14
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30127

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