The mammalian Golgi apparatus during M-phase

Misteli, T. (1996) The mammalian Golgi apparatus during M-phase. Progress in cell cycle research, 2. pp. 267-77. ISSN 1087-2957 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/9552401
DOI: 10.1007/978-1-4615-5873-6_24

Abstract

The Golgi apparatus in mammalian cells disassembles into several thousand vesicles as cells enter M-phase. Disassembly is dependent on the action of cdc2-kinase and at least two pathways contribute to the fragmentation: One involves the budding of COP-coated vesicles from Golgi cisternae with concomitant inhibition of fusion with their target membranes, the other is a less well characterised COP-independent pathway. During telophase, the Golgi fragments reassemble and fuse into a fully functional Golgi stack, using at least two distinct fusion pathways. The morphological changes of the Golgi apparatus during M-phase offer an ideal system to study how cellular organelles are generated and how their structure is maintained during interphase.

Item Type: Paper
Uncontrolled Keywords: Animals CDC2 Protein Kinase/metabolism Golgi Apparatus/metabolism/ ultrastructure Humans Interphase/physiology Mammals Membrane Fusion/physiology Membrane Proteins/metabolism Microscopy, Electron Mitosis/ physiology
Subjects: organs, tissues, organelles, cell types and functions > organelles, types and functions > golgi
organs, tissues, organelles, cell types and functions > tissues types and functions > membranes
Investigative techniques and equipment > microscopy
organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis
CSHL Authors:
Communities: CSHL labs > Spector lab
Depositing User: Kathleen Darby
Date Deposited: 13 May 2014 17:00
Last Modified: 13 May 2014 17:00
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30090

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