Dual functions of the KNOTTED1 homeodomain: sequence-specific DNA binding and regulation of cell-to-cell transport

Bolduc, N., Hake, S., Jackson, D. (2008) Dual functions of the KNOTTED1 homeodomain: sequence-specific DNA binding and regulation of cell-to-cell transport. Science Signaling, 1 (23). pe28.

URL: http://www.ncbi.nlm.nih.gov/pubmed/18544748
DOI: 10.1126/scisignal.123pe28

Abstract

Homeodomain proteins are well-characterized developmental regulators that control expression of target genes through sequence-specific DNA binding. The homeodomain forms a trihelical structure, with the third helix conferring specific interactions with the DNA major groove. A specific class of plant homeodomain proteins, called KNOX [KNOTTED1 (KN1)-like homeobox], also has the ability to signal between cells by directly trafficking through intercellular channels called plasmodesmata. Trafficking is mediated by a signal that is also contained within the homeodomain. Movement protein binding protein 2C was identified as a protein that interacts with the KN1 homeodomain and regulates the cell-to-cell trafficking of KN1 by sequestering the protein on microtubules. Therefore, KN1 has multiple potential cellular addresses, each of which is conferred by its homeodomain.

Item Type: Paper
Uncontrolled Keywords: Cell Communication DNA, Plant/*metabolism DNA-Binding Proteins/chemistry/metabolism Homeodomain Proteins/*chemistry/genetics/*metabolism Mutation Plant Proteins/*chemistry/genetics/*metabolism Signal Transduction Solanum tuberosum/enzymology Tobacco/enzymology Transcription, Genetic
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > homeodomain protein
organism description > plant
organs, tissues, organelles, cell types and functions > tissues types and functions > transport > trans-membrane transport
CSHL Authors:
Communities: CSHL labs > Jackson lab
Depositing User: Matt Covey
Date: 2008
Date Deposited: 12 May 2014 14:58
Last Modified: 12 May 2014 14:58
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30045

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