Apoptosis and the shape of death

Hengartner, M. O. (1997) Apoptosis and the shape of death. Developmental Genetics, 21 (4). pp. 245-8. ISSN 0192-253X (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/9438338
DOI: 10.1002/(SICI)1520-6408(1997)21:4<245::AID-DVG1>3.0.CO;2-7

Abstract

Programmed cell death is a common cell fate in most if not all multicellular animals. It is used extensively during development, as well as later in life, to eliminate cells that are either useless or potentially detrimental to the organism. Programmed cell death is basically cell suicide, in the sense that the cell that is to die actively participates in— and often itself induces— its own demise and removal from the organism. Proper control of programmed cell death is crucial, and breakdown in the regulation of this process can result in a number of pathologies: inactivation of the death program has been associated with the development of cancer and autoimmune diseases, whereas aberrant activation of the apoptotic machinery is thought to contribute to the extensive cell deaths observed in neurodegenerative diseases and stroke [Thompson, 1995; Vaux, 1993].

Item Type: Paper
Uncontrolled Keywords: Animals Apoptosis Cell Size Cells/ pathology Humans Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > cell types and functions
CSHL Authors:
Communities: CSHL labs > Hengartner lab
Depositing User: Kathleen Darby
Date: 1997
Date Deposited: 07 May 2014 15:34
Last Modified: 07 May 2014 15:34
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30030

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