Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans

Hengartner, M. O. (July 1997) Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans. Experimental Gerontology, 32 (4-5). pp. 363-74. ISSN 0531-5565 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/9315441
DOI: 10.1016/S0531-5565(96)00167-2

Abstract

The nematode Caenorhabditis elegans has been used extensively as a model system for the study of basic biological processes. In this species, apoptosis and aging are both under genetic control. Molecular studies have shown that the death machinery that kills C. elegans cells has remained conserved through evolution and also functions to promote apoptotic death in mammalian cells. At least some of the genes that affect C. elegans life span are also evolutionarily conserved; whether the vertebrate homologs of these genes also influence life span remains to be determined. Although a large number of mutations have been isolated that affect either apoptosis or aging in C. elegans, there is so far no evidence that the genetic pathways that control these processes might overlap.

Item Type: Paper
Uncontrolled Keywords: Aging/ physiology Animals Apoptosis/ physiology Caenorhabditis elegans/ genetics/growth & development/ physiology Longevity/physiology Research Support, Non-U.S. Gov't
Subjects: organism description > animal > C elegans
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > tissues types and functions > biological clock
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell death
CSHL Authors:
Communities: CSHL labs > Hengartner lab
Depositing User: Kathleen Darby
Date: July 1997
Date Deposited: 07 May 2014 19:24
Last Modified: 07 May 2014 19:24
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30012

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