Learning mechanisms: the case for CaM-KII

Lisman, J., Malenka, R. C., Nicoll, R. A., Malinow, R. (June 1997) Learning mechanisms: the case for CaM-KII. Science, 276 (5321). pp. 2001-2.

URL: http://www.ncbi.nlm.nih.gov/pubmed/9221509
DOI: 10.1126/science.276.5321.2001

Abstract

Long-term potentiation (LTP) is a strengthening of synapses in the brain that is thought to underlie learning and memory. Now in this issue Barria et al. show that the persistent change is likely to be phosphorylation of the postsynaptic glutamate receptor known as the AMPA receptor. Lisman et al. in their Perspective discuss how this phosphorylation may function to cause LTP and how these results fit in with other findings in the literature.

Item Type: Paper
Additional Information: 0036-8075 (Print) Journal Article
Uncontrolled Keywords: Animals Ca(2+)-Calmodulin Dependent Protein Kinase/*metabolism Hippocampus/metabolism *Long-Term Potentiation Memory Mice Mice, Transgenic Phosphorylation Phototransduction Receptors, AMPA/*metabolism Signal Transduction Synapses/*metabolism *Synaptic Transmission
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal behavior > memory
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein expression > phosphorylation
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organism description > animal behavior > vision
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Kathleen Darby
Date: 27 June 1997
Date Deposited: 08 May 2014 14:30
Last Modified: 08 May 2014 14:30
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30001

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