Regulation of gene expression and its role in long-term memory and synaptic plasticity

Tully, T. (April 1997) Regulation of gene expression and its role in long-term memory and synaptic plasticity. Proc Natl Acad Sci U S A, 94 (9). pp. 4239-41. ISSN 0027-8424 (Print)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/9113972

Abstract

Histories of science yet to be written will view the latter half of this century as the Age of Molecular Genetics. From a flash of insight that yielded the double helix (1) to the first genetic clone of a mammal (2), molecular genetics has invaded every aspect of biological research. Initially, this molecular-genetic onslaught was limited to species, such as bacteria, yeast, nematodes, and fruit flies, whose size and life cycle constituted an economy of scale that was advantageous to breeding (3). With the introduction of gene-knockout techniques to mice (4), however, molecular genetics now is storming mammals (5, 6). In the broadest sense, the recent paper by Guzowski and McGaugh (7) represents a vanguard of this invasion. By using antisense oligonucleotides as “pharmaceutical” disruptors of gene expression, they have liberated molecular genetics from breeding. Endogenous regulation of gene expression has been outflanked by exogenous control.

Item Type: Paper
Uncontrolled Keywords: Animals Cyclic AMP Response Element-Binding Protein/ metabolism Gene Expression Regulation Memory/ physiology Models, Biological Models, Psychological Neuronal Plasticity/ genetics Synapses/ physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > Cyclic AMP
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: Kathleen Darby
Date: 29 April 1997
Date Deposited: 08 May 2014 17:42
Last Modified: 09 Nov 2017 17:24
PMCID: PMC33661
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29980

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