Identification of protein coding regions in the human genome by quadratic discriminant analysis

Zhang, M. Q. (January 1997) Identification of protein coding regions in the human genome by quadratic discriminant analysis. Proceedings of the National Academy of Sciences, 94 (2). pp. 565-8. ISSN 0027-8424 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/9012824

Abstract

A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: HEXON [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156-5163] (based on linear discriminant analysis) and GRAIL2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261-11265] (based on neural networks). A computer program called MZEF is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons.

Item Type: Paper
Uncontrolled Keywords: Base Sequence Exons Genes Human Genome Project Humans Molecular Sequence Data Multivariate Analysis Proteins/genetics Research Support, U.S. Gov't, P.H.S. Sequence Analysis, DNA/ methods Software
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > exons > protein coding exon
CSHL Authors:
Communities: CSHL labs > Zhang lab
Depositing User: Kathleen Darby
Date: 21 January 1997
Date Deposited: 08 May 2014 18:31
Last Modified: 08 May 2014 18:31
PMCID: PMC19553
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29970

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