Promotion of dendritic growth by CPG15, an activity-induced signaling molecule

Nedivi, E., Wu, G. Y., Cline, H. T. (September 1998) Promotion of dendritic growth by CPG15, an activity-induced signaling molecule. Science, 281 (5384). pp. 1863-6. ISSN 0036-8075 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/9743502
DOI: 10.1126/science.281.5384.1863

Abstract

Activity-independent and activity-dependent mechanisms work in concert to regulate neuronal growth, ensuring the formation of accurate synaptic connections. CPG15, a protein regulated by synaptic activity, functions as a cell-surface growth-promoting molecule in vivo. In Xenopus laevis, CPG15 enhanced dendritic arbor growth in projection neurons, with no effect on interneurons. CPG15 controlled growth of neighboring neurons through an intercellular signaling mechanism that requires its glycosylphosphatidylinositol link. CPG15 may represent a new class of activity-regulated, membrane-bound, growth-promoting proteins that permit exquisite spatial and temporal control of neuronal structure.

Item Type: Paper
Uncontrolled Keywords: Animals Dendrites/ physiology/ultrastructure Genetic Vectors Glycosylphosphatidylinositols/metabolism Image Processing, Computer-Assisted Interneurons/cytology/physiology Ligands Membrane Proteins/genetics/metabolism/ physiology Microscopy, Confocal Nerve Tissue Proteins Neuronal Plasticity Neurons/cytology/physiology Recombinant Proteins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Signal Transduction Superior Colliculus/cytology/metabolism Vaccinia virus/genetics/physiology Xenopus laevis
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons

bioinformatics > genomics and proteomics > small molecules > cofactors > ligands
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
organism description > animal > Frog > xenopus
CSHL Authors:
Communities: CSHL labs > Cline lab
CSHL labs > Stillman lab
Depositing User: Kathleen Darby
Date: 18 September 1998
Date Deposited: 01 May 2014 14:11
Last Modified: 01 May 2014 14:11
PMCID: PMC3088013
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29919

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