Silencing the controversy in LTP?

Malinow, R. (1998) Silencing the controversy in LTP? Neuron, 21 (6). pp. 1226-7. ISSN 0896-6273 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/9883714
DOI: 10.1016/S0896-6273(00)80640-6

Abstract

Why has there been such long-term controversy (LTC) over the mechanisms underlying long-term potentiation (LTP)? The inability to resolve this debate may have many sources, including intrinsically empirical as well as sociological factors. Certainly, the regulatory mechanisms underlying modification of transmission in the brain are likely to be complex, and the tools we posses are relatively coarse. In this light, the fact that scientists generally are clever enough to think of mechanistic scenarios that cannot be disproved by existing empirical tools complicates the search. Furthermore, the imbalanced impact of positive results over negative results, or the natural bias of scientists to champion their own point of view, can prolong the discourse. Whatever the source, the field of LTP has been mired with LTC to the point that most consider it a long-term tar pit (LTTP). How does one escape eternal fossilization? It can only be hoped that over time different groups, using different techniques and asking questions related to different aspects of synaptic transmission modulation, will provide the cleansing solvent.

Item Type: Paper
Uncontrolled Keywords: Animals Hippocampus/ physiology Long-Term Potentiation Neurons/ physiology Receptors, N-Methyl-D-Aspartate/physiology Synapses/ physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons

organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Kathleen Darby
Date Deposited: 01 May 2014 17:32
Last Modified: 01 May 2014 17:32
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29915

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