Crossing the line between RNA polymerases: transcription of human snRNA genes by RNA polymerases II and III

Henry, R. W., Ford, E., Mital, R., Mittal, V., Hernandez, N. (1998) Crossing the line between RNA polymerases: transcription of human snRNA genes by RNA polymerases II and III. Cold Spring Harbor Symposia on Quantitative Biology, 63. pp. 111-20. ISSN 00917451 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10384275
DOI: 10.1101/sqb.1998.63.111

Abstract

In eukaryotic organisms, transcription is carried out bythree RNA polymerases, RNA polymerases I, II, and III.In general, these RNA polymerases recognize promoterswith very different structures. For example, RNA polymerase II (pol II) promoters are mostly located upstreamof the transcription start site, whereas RNA polymeraseIII (pol III) promoters are mostly located downstreamfrom the transcription start site. The U1, U2, and U6small nuclear RNA (snRNA) genes, which encode essential RNA components of small nuclear ribonucleoproteinparticles (snRNPs) involved in mRNA splicing, serve asrepresentative models for a group of pol II and pol IIIgenes with unusually similar promoters. The pol II U1and U2 promoters contain a distal sequence element(DSE) and a proximal sequence element (PSE), whereasthe pol III U6 promoter contains a DSE, a PSE, and aTATA box, all located upstream of the transcriptionalstart sit...

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Humans Molecular Sequence Data Promoter Regions (Genetics) Protein Biosynthesis RNA Polymerase II/ metabolism RNA Polymerase III/ metabolism RNA, Small Nuclear/ genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Transcription Factors/chemistry/ metabolism Transcription, Genetic
Subjects: bioinformatics > genomics and proteomics > design > amino acid design
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > RNA polymerase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > snRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Hernandez lab
CSHL labs > Mittal lab
Depositing User: Kathleen Darby
Date: 1998
Date Deposited: 01 May 2014 17:55
Last Modified: 07 May 2014 13:13
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29893

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving