Apoptosis. Death by crowd control

Hengartner, M. (August 1998) Apoptosis. Death by crowd control. Science, 281 (5381). pp. 1298-9. ISSN 0036-8075 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/9735047
DOI: 10.1126/science.281.5381.1298

Abstract

Cells often die by way of a controlled suicide called apoptosis. The proteins most responsible for the deed are caspases, specific proteases that are carefully regulated in the cell so that they only become activated when absolutely necessary. In his Perspective, Hengartner discusss results reported by Yang et al. in the same issue on how some of the central caspases responsible for cell death, such as CED-3, are activated by oligomerization, a process that is regulated by the anti-death protein CED-9, a member of the large Bcl-2 family.

Item Type: Paper
Uncontrolled Keywords: Animals Apoptosis Apoptosis Regulatory Proteins Caenorhabditis elegans Proteins Calcium-Binding Proteins/chemistry/metabolism Caspases Cysteine Endopeptidases/chemistry/ metabolism Enzyme Activation Enzyme Precursors/metabolism Helminth Proteins/chemistry/metabolism Models, Biological Proteins/metabolism Proto-Oncogene Proteins/chemistry/metabolism
Subjects: organism description > animal > C elegans
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > Protease > caspases
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
CSHL Authors:
Communities: CSHL labs > Hengartner lab
Depositing User: Kathleen Darby
Date: 28 August 1998
Date Deposited: 05 May 2014 13:49
Last Modified: 05 May 2014 13:49
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29892

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