Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning

Giese, K. P., Storm, J. F., Reuter, D., Fedorov, N. B., Shao, L. R., Leicher, T., Pongs, O., Silva, A. J. (September 1998) Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learning and Memory, 5 (4-5). pp. 257-73. ISSN 1072-0502 (Print)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/10454353
DOI: 10.1101/lm.5.4.257

Abstract

A-type K+ channels are known to regulate neuronal firing, but their role in repetitive firing and learning in mammals is not well characterized. To determine the contribution of the auxiliary K+ channel subunit Kvbeta1.1 to A-type K+ currents and to study the physiological role of A-type K+ channels in repetitive firing and learning, we deleted the Kvbeta1.1 gene in mice. The loss of Kvbeta1.1 resulted in a reduced K+ current inactivation in hippocampal CA1 pyramidal neurons. Furthermore, in the mutant neurons, frequency-dependent spike broadening and the slow afterhyperpolarization (sAHP) were reduced. This suggests that Kvbeta1.1-dependent A-type K+ channels contribute to frequency-dependent spike broadening and may regulate the sAHP by controlling Ca2+ influx during action potentials. The Kvbeta1.1-deficient mice showed normal synaptic plasticity but were impaired in the learning of a water maze test and in the social transmission of food preference task, indicating that the Kvbeta1.1 subunit contributes to certain types of learning and memory.

Item Type: Paper
Uncontrolled Keywords: Action Potentials/physiology Animals Calcium/physiology Cues Evoked Potentials/ physiology Food Preferences Hippocampus/pathology/ physiology/physiopathology Kv1.1 Potassium Channel Large-Conductance Calcium-Activated Potassium Channel beta Subunits Learning Disorders/genetics/pathology/ physiopathology Maze Learning/ physiology Mice Mice, Knockout Neuronal Plasticity Potassium Channels/deficiency/genetics/ physiology Potassium Channels, Voltage-Gated Pyramidal Cells/pathology/ physiology Research Support, Non-U.S. Gov't Social Behavior Synapses/physiology
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal behavior > learning
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons

organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs
Depositing User: Kathleen Darby
Date: September 1998
Date Deposited: 01 May 2014 19:40
Last Modified: 01 May 2014 19:40
PMCID: PMC311244
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29883

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