LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become

Constantine-Paton, M., Cline, H. T. (1998) LTP and activity-dependent synaptogenesis: the more alike they are, the more different they become. Current Opinion in Neurobiology, 8 (1). pp. 139-48. ISSN 0959-4388

URL: http://www.ncbi.nlm.nih.gov/pubmed/9568401
DOI: 10.1016/S0959-4388(98)80017-2

Abstract

Recent data suggest that long-term potentiation and activity-dependent synaptogenesis share the same mechanism at the initiation stage during which NMDA receptor activity is necessary to increase the postsynaptic response via AMPA receptor currents. However, several fundamental differences between the environments of young and mature synapses and the neurons that support them suggest that the same cellular mechanism is facilitated by very different parameters in the young versus the mature brain.

Item Type: Paper
Additional Information: 0959-4388 (Print) Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review
Uncontrolled Keywords: Animals Brain/cytology/*growth & development/physiology Humans Long-Term Potentiation/*physiology Receptors, AMPA/physiology Receptors, N-Methyl-D-Aspartate/physiology Synapses/*physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
organs, tissues, organelles, cell types and functions > organs types and functions > brain
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organs, tissues, organelles, cell types and functions > tissues types and functions > synaptogenesis
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: Kathleen Darby
Date Deposited: 05 May 2014 14:52
Last Modified: 05 May 2014 14:52
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29878

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