HIV and SIV Nef modulate signal transduction and protein sorting in T cells

Skowronski, J., Greenberg, M. E., Lock, M., Mariani, R., Salghetti, S., Swigut, T., Iafrate, A. J. (1999) HIV and SIV Nef modulate signal transduction and protein sorting in T cells. Cold Spring Harb Symp Quant Biol, 64. pp. 453-63. ISSN 0091-7451 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/11232322
DOI: 10.1101/sqb.1999.64.453

Abstract

One striking aspect of immunodeficiency viruses istheir ability to replicate and maintain persistent infectionin the face of the host immune response and to eventuallyovercome this response (Desrosiers 1999). The progressive loss of CD4+ T lymphocytes, the hallmark of AIDSinfection, reflects the host's inability to regenerate thesecells as immunodeficiency viruses disrupt the normalfunction of the lymphoid organs. The ensuing havocwrought on the immune system results, perhaps directly,from viral gene expression in the infected cells. Unlikesimple retroviruses, the genomes of human and simianimmunodeficiency viruses (HIV and SIV) encode severalauxiliary proteins that modulate the normal function ofthe infected cells to maximize viral replication in the infected host, and these factors are important determinantsof the clinical outcome of immunodeficiency virus infection (Cullen 1998; Desrosiers et al. 1998; Emerman andMalim 1998). Some of these proteins, such as Nef andVpu, interact with the protein sorting and general signaltransduction machineries in T cells and macrophages (Peter 1998). Other auxiliary proteins, such as Vpr and Vpx,interact with the cell cycle and nuclear transport machineries.

Item Type: Paper
Uncontrolled Keywords: Adaptor Protein Complex alpha Subunits Adaptor Proteins, Vesicular Transport Amino Acid Sequence Animals Antigens, CD3/metabolism Antigens, CD4/chemistry/genetics/metabolism Down-Regulation Gene Products, nef/genetics/ metabolism HIV-1/genetics/ metabolism Histocompatibility Antigens Class I/metabolism Humans Membrane Proteins/metabolism Mice Mice, Transgenic Models, Biological Molecular Sequence Data Protein Structure, Tertiary Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Signal Transduction Simian immunodeficiency virus/genetics/ metabolism T-Lymphocytes/ metabolism/ virology src Homology Domains
Subjects: diseases & disorders > viral diseases > HIV
diseases & disorders > viral diseases > SIV
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells

organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
CSHL Authors:
Communities: CSHL labs > Skowronski lab
CSHL labs > Tansey lab
Depositing User: Kathleen Darby
Date: 1999
Date Deposited: 22 Apr 2014 17:21
Last Modified: 30 Apr 2014 17:15
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29865

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