How cells use proteolysis to control their growth

Tansey, W. P. (December 1999) How cells use proteolysis to control their growth. Molecular Medicine, 5 (12). pp. 773-82. ISSN 1076-1551 (Print)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/10666476

Abstract

Protein destruction may seem like a strange way for a cell to control its growth. The entire process by which cells multiply is based on synthesisthe duplication of almost every molecule in the cell. If protein synthesis is one of the foundations of growth, then why are so many proteins destroyed as one cell becomes two? The answer to this question is control. The process of cell duplication is, of course, more complicated than simply replicating the cellular contents and dividing. Survival of all eukaryotic cells depends on their ability to regulate how and when they grow. To persist, cells must multiply only in response to specific signals, they must have mechanisms to detect errors in the duplication process, and they must establish a defined sequence for the events of duplication, so that DNA replication, for example, always precedes cell division. In addition to synthesis, therefore, an important part of growth is maintaining tight control over all of the proteins needed to make a new cell. Protein destruction-proteolysisplays a pivotal role in controlling the activity of these proteins.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Cycle Proteins/physiology Cell Division/physiology Endopeptidases/ metabolism Eukaryotic Cells/ cytology/ enzymology/metabolism Humans Hydrolysis
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
CSHL Authors:
Communities: CSHL labs > Tansey lab
Depositing User: Kathleen Darby
Date: December 1999
Date Deposited: 23 Apr 2014 15:59
Last Modified: 23 Apr 2014 16:16
PMCID: PMC2230494
URI: http://repository.cshl.edu/id/eprint/29860

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