latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant

Pinto, S., Quintana, D. G., Smith, P., Mihalek, R. M., Hou, Z. H., Boynton, S., Jones, C. J., Hendricks, M., Velinzon, K., Wohlschlegel, J. A., Austin, R. J., Lane, W. S., Tully, T., Dutta, A. (May 1999) latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. Neuron, 23 (1). pp. 45-54. ISSN 0896-6273 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10402192
DOI: 10.1016/S0896-6273(00)80752-7

Abstract

The Drosophila latheo (lat) gene was identified in a behavioral screen for olfactory memory mutants. The original hypomorphic latP1 mutant (Boynton and Tully, 1992) shows a structural defect in adult brain. Homozygous lethal lat mutants lack imaginal discs, show little cell proliferation in the CNS of third instar larvae, and die as early pupae. latP1 was cloned, and all of the above mentioned defects of hypomorphic or homozygous lethal lat mutants were rescued with a lat+ transgene. lat encodes a novel protein with homology to a subunit of the origin recognition complex (ORC). Human and Drosophila LAT both associate with ORC2 and are related to yeast ORC3, suggesting that LAT functions in DNA replication during cell proliferation.

Item Type: Paper
Uncontrolled Keywords: Abnormalities/genetics Amino Acid Sequence/genetics Animals Animals, Genetically Modified Brain/abnormalities/pathology/physiopathology Cell Division/physiology Central Nervous System/pathology DNA-Binding Proteins/ genetics Drosophila/ genetics/growth & development Drosophila Proteins Memory/ physiology Memory Disorders/genetics Molecular Sequence Data Mutation/ genetics/physiology Neurons/ pathology Olfactory Pathways/ physiopathology Origin Recognition Complex Pupa/physiology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Sequence Homology, Amino Acid Transcription, Genetic/genetics Transgenes/physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
organism description > animal > insect > Drosophila
organs, tissues, organelles, cell types and functions > organs types and functions > brain
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
organism description > animal behavior > olfactory
CSHL Authors:
Communities: CSHL labs > Herr lab
CSHL labs > Stillman lab
CSHL labs > Tully lab
Depositing User: Kathleen Darby
Date: May 1999
Date Deposited: 28 Apr 2014 13:56
Last Modified: 30 Apr 2014 17:36
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29829

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