The Drosophila dCREB2 gene affects the circadian clock

Belvin, M. P., Zhou, H., Yin, J. C. (April 1999) The Drosophila dCREB2 gene affects the circadian clock. Neuron, 22 (4). pp. 777-87. ISSN 0896-6273 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10230797
DOI: 10.1016/S0896-6273(00)80736-9

Abstract

We report the role of dCREB2, the Drosophila homolog of CREB/CREM, in circadian rhythms. dCREB2 activity cycles with a 24 hr rhythm in flies, both in a light:dark cycle and in constant darkness. A mutation in dCREB2 shortens circadian locomotor rhythm in flies and dampens the oscillation of period, a known clock gene. Cycling dCREB2 activity is abolished in a period mutant, indicating that dCREB2 and Period affect each other and suggesting that the two genes participate in the same regulatory feedback loop. We propose that dCREB2 supports cycling of the Period/Timeless oscillator. These findings support CREB's role in mediating adaptive behavioral responses to a variey of environmental stimuli (stress, growth factors, drug addiction, circadian rhythms, and memory formation) in mammals and long-term memory formation and circadian rhythms in Drosophila.

Item Type: Paper
Uncontrolled Keywords: Animals Circadian Rhythm/ physiology Cyclic AMP Response Element-Binding Protein/ genetics Drosophila/ genetics Feedback Female Genes, Insect Luciferases/metabolism Mutation Oscillometry Phenotype Recombinant Fusion Proteins/metabolism Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > CREB
organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor > Cyclic AMP
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > luciferase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
CSHL Authors:
Communities: CSHL labs > Yin lab
Depositing User: Kathleen Darby
Date: April 1999
Date Deposited: 28 Apr 2014 16:14
Last Modified: 30 Apr 2014 17:51
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29815

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