Rac and Cdc42 effectors

Boettner, B., Van Aelst, L. (1999) Rac and Cdc42 effectors. Progress in molecular and subcellular biology, 22. pp. 135-58. ISSN 0079-6484 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10081068
DOI: 10.1007/978-3-642-58591-3_7

Abstract

Rac and Cdc42, like all members of the Ras superfamily, act as molecular switches, cycling between an inactive GDP-bound state and an active GTPbound state. Until recently, members of the Rho-subfamily were believed to be primarily involved in the regulation of cytoskeletal organization in response to extracellular growth factors. However, studies from numerous groups over the past few years have revealed that the Rho-GTPases play crucial roles in a wide variety of biological processes such as transcriptional regulation, cell growth control, membrane trafficking including endocytosis, exocytosis and phagocytosis, as well as development (Fig. 1). The signal transduction pathways mediating these biological phenomena are complex and intricately interwoven. A major challenge has been the identification of downstream effector molecules by which Rac and Cdc42 mediate these activities. Numerous targets of Rac and Cdc42 have been identified (Fig. 2) and further characterization of some of them has led to a better understanding of the function Rac and Cdc42 display at the molecular level. The different Rac and Cdc42 specific effectors and our current understanding of their physiological roles are the major focus of this chapter.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Cycle Proteins/ metabolism GTP-Binding Proteins/ metabolism Humans Protein-Serine-Threonine Kinases/ metabolism Proto-Oncogene Proteins c-akt Research Support, Non-U.S. Gov't cdc42 GTP-Binding Protein cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Rac
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTP binding protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Sordella lab
CSHL labs > Van Aelst lab
Depositing User: Kathleen Darby
Date Deposited: 30 Apr 2014 13:40
Last Modified: 30 Apr 2014 13:40
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29801

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