Clinical implications of p53 mutations

Wallace-Brodeur, R. R., Lowe, S. W. (January 1999) Clinical implications of p53 mutations. Cellular and Molecular Life Sciences , 55 (1). pp. 64-75. ISSN 1420-682X (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/10065152
DOI: 10.1007/s000180050270

Abstract

The ultimate goal of basic cancer research is to provide a theoretical foundation for rational approaches to improve cancer therapy. Our extensive insight into the biology of the p53 tumour suppressor and the clinical behaviour of tumours harbouring p53 mutations indicates that information concerning p53 will be useful in diagnosis and prognosis, and may ultimately produce new therapeutic strategies. At the same time, efforts to understand the clinical implications of p53 mutations have revealed conceptual and technical limitations in translating basic biology to the clinic. The lessons learned from p53 may lay the groundwork for future efforts to synthesize cancer gene function, cancer genetics and cancer therapy.

Item Type: Paper
Uncontrolled Keywords: Antineoplastic Agents/toxicity Apoptosis/genetics Cell Cycle/genetics Drug Resistance/genetics Genes, Tumor Suppressor/genetics Genes, p53/ genetics Humans Mutation/ genetics Neoplasms/diagnosis/ genetics/therapy Protein Binding/genetics Research Support, U.S. Gov't, P.H.S.
Subjects: diseases & disorders > neoplasms
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: Kathleen Darby
Date: January 1999
Date Deposited: 30 Apr 2014 14:23
Last Modified: 30 Apr 2014 14:23
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29797

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