Computational neuroanatomy and co-expression of genes in the adult mouse brain, analysis tools for the Allen Brain Atlas

Grange, Pascal, Hawrylycz, Michael, Mitra, Partha P. (2013) Computational neuroanatomy and co-expression of genes in the adult mouse brain, analysis tools for the Allen Brain Atlas. Quantitative Biology, 1 (1). pp. 91-100. ISSN 2095-4689

URL: http://link.springer.com/article/10.1007%2Fs40484-...
DOI: 10.1007/s40484-013-0011-5

Abstract

We review quantitative methods and software developed to analyze genome-scale, brain-wide spatially-mapped gene-expression data. We expose new methods based on the underlying high-dimensional geometry of voxel space and gene space, and on simulations of the distribution of co-expression networks of a given size. We apply them to the Allen Atlas of the adult mouse brain, and to the coexpression network of a set of genes related to nicotine addiction retrieved from the NicSNP database. The computational methods are implemented in BrainGeneExpressionAnalysis (BGEA), a Matlab toolbox available for download.

Item Type: Paper
Subjects: Investigative techniques and equipment > brain atlas
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
organism description > animal > mammal > rodent > mouse
neurobiology
Investigative techniques and equipment > Whole Brain Circuit Mapping
CSHL Authors:
Communities: CSHL labs > Mitra lab
Depositing User: Matt Covey
Date: 2013
Date Deposited: 21 Apr 2014 18:33
Last Modified: 21 Apr 2014 18:33
URI: http://repository.cshl.edu/id/eprint/29775

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