Unlocking the Treasure Trove: From Genes to Schizophrenia Biology

McCarthy, S. E., McCombie, W. R., Corvin, A. (2014) Unlocking the Treasure Trove: From Genes to Schizophrenia Biology. Schizophrenia Bulletin, 40 (3). pp. 492-496. ISSN 0586-7614

URL: http://www.ncbi.nlm.nih.gov/pubmed/24674812
DOI: 10.1093/schbul/sbu042

Abstract

Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function in model systems. The confluence of these two research fields-gene discovery and functional biology-may offer novel insights into schizophrenia etiology. We review recent advances in these fields, consider the likely obstacles to progress, and consider strategies as to how these can be overcome.

Item Type: Paper
Uncontrolled Keywords: Crispr genomics model schizophrenia sequencing systems
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
diseases & disorders > mental disorders
diseases & disorders > mental disorders > schizophrenia
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes
Investigative techniques and equipment > assays > next generation sequencing
Investigative techniques and equipment > assays > whole genome sequencing
CSHL Authors:
Communities: CSHL labs > McCombie lab
Depositing User: Matt Covey
Date Deposited: 11 Apr 2014 19:44
Last Modified: 18 Dec 2014 17:18
PMCID: PMC3984532
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29738

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