Tactile experience induces c-fos expression in rat barrel cortex

Filipkowski, R. K., Rydz, M., Berdel, B., Morys, J., Kaczmarek, L. (March 2000) Tactile experience induces c-fos expression in rat barrel cortex. Learning & Memory, 7 (2). pp. 116-122. ISSN 1072-0502

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URL: http://www.ncbi.nlm.nih.gov/pubmed/10753978
DOI: 10.1101/lm.7.2.116

Abstract

Understanding gene expression that is responsive to sensory stimulation is central to elucidate molecular mechanisms underlying neuronal plasticity. In this study we demonstrate two new methods of stimulating whiskers that provide major sensory input to rat neocortex. In the first paradigm, animals were placed on the top of a cylinder and their vibrissae were brushed by hand, In the second paradigm, animals were placed for a brief period or time into a new, wired cage resulting in vibrissae stimulation when they explored the new environment. Both approaches induced c-Fos expression in barrel cortex corresponding to the stimulated vibrissae, especially in layer IV. Layers II/III and V/VI also showed c-Fos induction, but there were no detectable changes in layer VIb. The majority of c-Fos-expressing cells are probably not inhibitory neurons, because they do not show parvalbumin staining. Both paradigms, in contrast to the previous methods, are simple to use and do not require anesthesia, restraint of animals, or elaborate experimental setups.

Item Type: Paper
Additional Information: Learn. Mem.
Uncontrolled Keywords: CALCIUM-BINDING PROTEINS EARLY GENE-EXPRESSION SOMATOSENSORY CORTEX CEREBRAL-CORTEX VISUAL-CORTEX TRANSCRIPTION FACTORS SENSORY STIMULATION TRANSIENT INCREASE NEURONAL-ACTIVITY NERVOUS-SYSTEM
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > tissues types and functions > barrel cortex
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat
CSHL Authors:
Communities: CSHL labs > Yin lab
Depositing User: Matt Covey
Date: March 2000
Date Deposited: 28 Jan 2014 21:30
Last Modified: 28 Jan 2014 21:30
PMCID: PMC311323
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29449

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