Risky immortalization by telomerase

Wang, J., Hannon, G. J., Beach, D. H. (June 2000) Risky immortalization by telomerase. Nature, 405 (6788). pp. 755-756. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/10866187
DOI: 10.1038/35015674

Abstract

Senescence naturally limits the proliferation of mammalian cells in culture, possibly by shortening the telomere regions at the ends of chromosomes during cell division1, 2. In support of this idea, introducing TERT, the catalytic subunit of telomerase — the enzyme that maintains chromosome ends — into certain cell types can extend their lifespan and potentially immortalize them3, 4. It has been proposed that treatment with exogenous TERT might be useful for cell-based therapies by allowing indefinite expansion of normal human cells without damaging their genomes5, 6. But we show here that TERT-driven cell proliferation is not genoprotective because it is associated with activation of the c-myc oncogene.

Item Type: Paper
Uncontrolled Keywords: HUMAN FIBROBLASTS EPITHELIAL-CELLS MYC ACTIVATION CANCER
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
Investigative techniques and equipment > cell culture
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > telomeres
CSHL Authors:
Communities: CSHL labs > Hannon lab
Depositing User: Matt Covey
Date: June 2000
Date Deposited: 28 Jan 2014 20:57
Last Modified: 28 Jan 2014 20:57
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29443

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