Recombination in telomere-length maintenance

Kass-Eisler, A., Greider, C. W. (April 2000) Recombination in telomere-length maintenance. Trends in Biochemical Sciences, 25 (4). pp. 200-206. ISSN 0968-0004

URL: http://www.ncbi.nlm.nih.gov/pubmed/10754555
DOI: 10.1016/S0968-0004(00)01557-7

Abstract

Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics.

Item Type: Paper
Uncontrolled Keywords: IMMORTAL HUMAN-CELLS SACCHAROMYCES-CEREVISIAE DNA-SEQUENCES YEAST KU LACKING TELOMERASE WILD-TYPE SENESCENCE IDENTIFICATION ORGANIZATION MECHANISM
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > recombination
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > telomerase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > telomeres
organism description > yeast
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: April 2000
Date Deposited: 28 Jan 2014 20:17
Last Modified: 28 Jan 2014 20:17
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29439

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