Postsynaptic CPG15 promotes synaptic maturation and presynaptic axon arbor elaboration in vivo

Cantallops, I., Haas, K., Cline, H. T. (October 2000) Postsynaptic CPG15 promotes synaptic maturation and presynaptic axon arbor elaboration in vivo. Nature Neuroscience, 3 (10). pp. 1004-1011. ISSN 1097-6256

URL: http://www.ncbi.nlm.nih.gov/pubmed/11017173
DOI: 10.1038/79823

Abstract

The formation of CNS circuits is characterized by the coordinated development of neuronal structure and synaptic function. The activity-regulated candidate plasticity gene 15 (cpg15) encodes a glycosylphosphatidylinositol (GPI)-linked protein whose in vivo expression increases the dendritic arbor growth rate of Xenopus optic tectal cells. We now demonstrate that tectal cell expression of CPG15 significantly increases the elaboration of presynaptic retinal axons by decreasing rates of branch retractions. Whole-cell recordings from optic tectal neurons indicate that CPG15 expression promotes retinotectal synapse maturation by recruiting functional AMPA receptors to synapses. Expression of truncated CPG15, lacking its GPI anchor, does not promote axon arbor growth and blocks synaptic maturation. These results suggest that CPG15 coordinately increases the growth of pre- and postsynaptic structures and the number and strength of their synaptic contacts.

Item Type: Paper
Uncontrolled Keywords: LONG-TERM POTENTIATION IN-VIVO DENDRITIC GROWTH AMPA RECEPTORS MAP FORMATION SYNAPSES PLASTICITY XENOPUS NEURONS EXPRESSION
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > axon > axon arbors
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors

organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
organism description > animal > Frog > xenopus
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: Matt Covey
Date: October 2000
Date Deposited: 30 Jan 2014 15:42
Last Modified: 30 Jan 2014 15:42
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29432

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