p53 and p73: seeing double?

Soengas, M. S., Lowe, S. W. (December 2000) p53 and p73: seeing double? Nature Genetics, 26 (4). pp. 391-392. ISSN 1061-4036

URL: http://www.ncbi.nlm.nih.gov/pubmed/11101828
DOI: 10.1038/82497

Abstract

Whereas p73 is closely related to the tumour-suppressor protein p53, its contribution to tumour suppression and the spatial and temporal regulation of its isoforms is unclear. It has now been established that p73 is a transcriptional target of E2F1. Its ability to induce apoptosis in TP53(-/-) cells indicates a tumour-control mechanism that runs parallel to but independent of that mediated by p53. The new results illustrate a complex cross-talk between p53, E2F1 and p73.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > tumor suppressor
CSHL Authors:
Communities: CSHL labs > Lowe lab
Depositing User: Matt Covey
Date: December 2000
Date Deposited: 29 Jan 2014 16:35
Last Modified: 29 Jan 2014 16:35
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29426

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