LTP mechanisms: from silence to four-lane traffic

Malinow, R., Mainen, Z. F., Hayashi, Y. (June 2000) LTP mechanisms: from silence to four-lane traffic. Current Opinion in Neurobiology, 10 (3). pp. 352-357. ISSN 0959-4388

URL: http://www.ncbi.nlm.nih.gov/pubmed/10851179
DOI: 10.1016/S0959-4388(00)00099-4

Abstract

Brief periods of strong neuronal activity induce long-lasting changes in synaptic function. This synaptic plasticity is thought to play important roles in learning and memory. One example - long-term potentation in the CA1 region of the hippocampus - has been studied extensively, and conflicting views regarding the underlying mechanisms have emerged. Recent findings, regarding basic properties of synaptic transmission, appear to reconcile these diverging views.

Item Type: Paper
Uncontrolled Keywords: LONG-TERM POTENTIATION DOMAIN-CONTAINING PROTEIN AMPA RECEPTOR GLUR2 GLUTAMATE RECEPTORS SYNAPTIC TRANSMISSION TRANSPORTER CURRENTS HIPPOCAMPAL SYNAPSES TRANSMITTER RELEASE NMDA RECEPTORS CA1 REGION
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > glutamate receptor
organism description > animal behavior > learning
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:
Communities: CSHL labs > Mainen lab
CSHL labs > Malinow lab
Depositing User: Matt Covey
Date: June 2000
Date Deposited: 30 Jan 2014 20:09
Last Modified: 30 Jan 2014 20:09
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29413

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