Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype

Friddle, C., Koskela, R., Ranade, K., Hebert, J., Cargill, M., Clark, C. D., McInnis, M., Simpson, S., McMahon, F., Stine, O. C., Meyers, D., Xu, J. F., MacKinnon, D., Swift-Scanlan, T., Jamison, K., Folstein, S., Daly, M., Kruglyak, L., Marr, T., DePaulo, J. R., Botstein, D. (January 2000) Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. American Journal of Human Genetics, 66 (1). pp. 205-215. ISSN 0002-9297

URL: http://www.ncbi.nlm.nih.gov/pubmed/10631152
DOI: 10.1086/302697

Abstract

A genome scan of similar to 12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.

Item Type: Paper
Uncontrolled Keywords: MANIC-DEPRESSIVE ILLNESS AFFECTIVE-DISORDER COMPLEX TRAITS GENETIC-TRAITS PEDIGREES CHROMOSOME-18 TRANSMISSION MARKERS HUMANS LOCUS
Subjects: diseases & disorders > mental disorders
diseases & disorders > mental disorders > mood disorders > depression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes
Investigative techniques and equipment > assays > whole genome sequencing
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: January 2000
Date Deposited: 30 Jan 2014 21:39
Last Modified: 30 Jan 2014 21:39
PMCID: PMC1288327
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29389

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