DNA-damage-induced checkpoint pathways in the nematode Caenorhabditis elegans

Hofmann, E. R., Milstein, S., Hengartner, M. O. (2000) DNA-damage-induced checkpoint pathways in the nematode Caenorhabditis elegans. Cold Spring Harbor Symposia on Quantitative Biology, 65. pp. 467-473. ISSN 0091-7451

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URL: http://www.ncbi.nlm.nih.gov/pubmed/12760063
DOI: 10.1101/sqb.2000.65.467

Abstract

Genomic instability is believed to be an enabling characteristic of cancer (Hanahan and Weinberg 2000).Therefore, it is not surprising that sophisticated mechanisms exist to maintain the integrity of the genome. Damage to DNA triggers checkpoint controls that result in cellcycle arrest and repair of the lesion (Nurse 1997, 2000;Weinert 1998). In multicellular organisms, when DNAdamage is extensive, these potentially harmful cells areeliminated by apoptosis (Enoch and Norbury 1995; Evanand Littlewood 1998). Defects in communications between DNA damage and the apoptotic program leads tothe survival of cells with unstable genomes vulnerable tooncogene activation, ultimately leading to tumor development (Morgan and Kastan 1997; Orr-Weaver andWeinberg 1998; Hanahan and Weinberg 2000). Geneticwork in yeast has greatly improved our understanding ofthe molecular mechanisms of DNA-damage-inducedcheckpoint arrest and repair. On the other hand, DNAdamage-induced apoptosis cannot be studied in yeasts, asthe apoptotic program is missing in both Saccharomycescerevisiae and Schizosaccharomyces pombe (Fraser andJames 1998)...

Item Type: Paper
Uncontrolled Keywords: PROGRAMMED CELL-DEATH C-ELEGANS GENETIC-CONTROL APOPTOSIS PROTEIN BCL-2 HOMOLOG REPLICATION MUTATIONS CLONING
Subjects: organism description > animal > C elegans
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
CSHL Authors:
Communities: CSHL labs > Hengartner lab
Depositing User: Matt Covey
Date: 2000
Date Deposited: 31 Jan 2014 16:04
Last Modified: 31 Jan 2014 16:04
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29379

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