The biochemistry of apoptosis

Hengartner, M. O. (October 2000) The biochemistry of apoptosis. Nature, 407 (6805). pp. 770-776. ISSN 0028-0836

URL: http://www.ncbi.nlm.nih.gov/pubmed/11048727
DOI: 10.1038/35037710

Abstract

Apoptosis - the regulated destruction of a cell - is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.

Item Type: Paper
Uncontrolled Keywords: PROGRAMMED CELL-DEATH BCL-X-L INDUCED-PROXIMITY MODEL CYTOCHROME-C CASPASE ACTIVATION NMR STRUCTURE COMPLEX FAMILY MITOCHONDRIA PROTEINS
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
CSHL Authors:
Communities: CSHL labs > Hengartner lab
Depositing User: Matt Covey
Date: October 2000
Date Deposited: 31 Jan 2014 16:25
Last Modified: 31 Jan 2014 16:25
Related URLs:
URI: http://repository.cshl.edu/id/eprint/29358

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